Liu, Xiaofeng; Shao, Ying; Sun, Jiangtao published the artcile< Ruthenium-Catalyzed Chemoselective N-H Bond Insertion Reactions of 2-Pyridones/7-Azaindoles with Sulfoxonium Ylides>, HPLC of Formula: 112-63-0, the main research area is alkyl pyridone preparation chemoselective; pyridone sulfoxonium ylide alkylation ruthenium catalyst; azaindole alkyl preparation chemoselective; sulfoxonium ylide azaindole alkylation ruthenium catalyst.
A ruthenium-catalyzed highly chemoselective N-alkylation of 2-pyridones I [R1 = H, 3-Cl, 5-Me, 4-(benzyloxy), etc.] has been developed, affording N-alkylated 2-pyridone derivatives II (R2 = Ph, n-Bu, thiophen-2-yl, etc.) in good yields and excellent N-selectivity. The key to achieve this unprecedented N-H rather than O-H insertion reaction is the use of CpRu(PPh3)2Cl as the catalyst and sulfoxonium ylides R2C(O)CH=S(O)(CH3)2 as the alkylation reagents. Moreover, this protocol is also amenable to 7-azaindoles III (R3 = H, 2-Et-3-Me, 4-Cl, etc.) by slightly varying the reaction conditions. Furthermore, sulfonium ylides are also suitable alkylation reagents, providing the N-alkylated 2-pyridones II in good selectivity.
Organic Letters published new progress about Alkylation catalysts (chemoselective). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics