Thiel, Cora S.; Vahlensieck, Christian; Bradley, Timothy; Tauber, Svantje; Lehmann, Martin; Ullrich, Oliver published the artcile< Metabolic Dynamics in Short- and Long-Term Microgravity in Human Primary Macrophages>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is metabolomics microgravity hypergravity metabolite amino acids glucose ketoleucine rhamnose; immune cells; metabolomics; microgravity; sounding rocket; spaceflight.
Microgravity acts on cellular systems on several levels. Cells of the immune system especially react rapidly to changes in gravity. In this study, we performed a correlative metabolomics anal. on short-term and long-term microgravity effects on primary human macrophages. We could detect an increased amino acid concentration after five minutes of altered gravity, that was inverted after 11 days of microgravity. The amino acids that reacted the most to changes in gravity were tightly clustered. The observed effects indicated protein degradation processes in microgravity. Further, glucogenic and ketogenic amino acids were further degraded to Glucose and Ketoleucine. The latter is robustly accumulated in short-term and long-term microgravity but not in hypergravity. We detected highly dynamic and also robust adaptative metabolic changes in altered gravity. Metabolomic studies could contribute significantly to the understanding of gravity-induced integrative effects in human cells.
International Journal of Molecular Sciences published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics