Palomba, Martina; Pompei, Sara; Roscini, Luca; Bagnoli, Luana published the artcile< Synthesis and biological evaluation of new indole and pyrrole carboxamides based on amino acids>, Formula: C19H34O2, the main research area is indolecarboxamide preparation antifungal; pyrrolecarboxamide preparation antifungal.
A series of indole-carboxamides I [R = H, 5-MeO, 5-F, 7-NO2, 5,6-di-MeO; R1 = i-Pr, CH(Me)Et, Bn, etc.; R2 = Me, Et] and II was synthesized through coupling reactions. Several substitutions on the aromatic ring and on the amino acids were well tolerated, and corresponding indole-carboxamides I and II were obtained with good yields. The same procedure could be also extended to pyrrole-carboxamides III. The compounds I [R = 5-MeO, 5,6-di-MeO, 7-NO2; R1 = i-Pr; R2 = Et] and III [R1 = i-Pr, R2 = Et] were screened for their antimicrobial activity against ten different yeast strains and only compounds I [R = 7-NO2, R1 = i-Pr, R2 = Et] and III [R1 = i-Pr, R2 = Et] showed an antifungal activity. Further explorations were required to clarify a potential applicability in biol. fields.
ARKIVOC (Gainesville, FL, United States) published new progress about Amides Role: PAC (Pharmacological Activity), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), PREP (Preparation), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics