Serafini, Marta; Cordero-Sanchez, Celia; Di Paola, Rosanna; Bhela, Irene P.; Aprile, Silvio; Purghe, Beatrice; Fusco, Roberta; Cuzzocrea, Salvatore; Genazzani, Armando A.; Riva, Beatrice; Pirali, Tracey published their research in Journal of Medicinal Chemistry on December 10 ,2020. The article was titled 《Store-Operated Calcium Entry as a Therapeutic Target in Acute Pancreatitis: Discovery and Development of Drug-Like SOCE Inhibitors》.Category: esters-buliding-blocks The article contains the following contents:
Store-operated calcium entry (SOCE) is important in the maintenance of calcium homeostasis and alterations in this mechanism are responsible for several pathol. conditions, including acute pancreatitis. Since the discovery of SOCE, many inhibitors have been identified and extensively used as chem. probes to better elucidate the role played by this cellular mechanism. Nevertheless, only a few have demonstrated drug-like properties so far. Here, we report a class of biphenyl triazoles among which stands out a lead compound, 34, that is endowed with an inhibitory activity at nanomolar concentrations, suitable pharmacokinetic properties, and in vivo efficacy in a mouse model of acute pancreatitis. The experimental process involved the reaction of 3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0Category: esters-buliding-blocks)
3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Category: esters-buliding-blocks They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics