Zhang, Liangliang; Oestreich, Martin published the artcile< Diastereotopic Group-Selective Intramolecular Aldol Reactions Initiated by Enantioselective Conjugate Silylation: Diastereodivergence Controlled by the Silicon Nucleophile>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is silyl benzoyl dihydroxyoctahydroindenone preparation isomerization crystal structure; crystal structure silyl benzoyl dihydroxyoctahydroindenone; mol structure silyl benzoyl dihydroxyoctahydroindenone; aryloxopentenyl cyclopentanedione enantioselective copper catalyzed silylation aldol cyclization; indenone silyl benzoyl preparation.
A reaction sequence consisting of enantioselective Cu-catalyzed conjugate silylation and diastereotopic group-selective aldol cyclization is reported. The diastereoselectivity of the intramol. aldol reaction depends on the Si nucleophile used, either Me2PhSiZnX·2LiX (trans) or Me2PhSiBpin (cis). The more basic Zn reagent and as such the very basic reaction medium also enable thermodynamically driven cis-to-trans isomerization by a retro-aldol-aldol process. A broad range of electron-withdrawing groups including electron-deficient heterocycles is compatible with the different procedures developed.
ACS Catalysis published new progress about Aldehydes, hydroxy Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics