Piesche, L.; Hilse, H.; Oehlke, J.; Schroetter, E.; Oehme, P. published the artcile< Substituted picolinic acids as DBH [dopamine β-hydroxylase] inhibitors. Inhibition of dopamine β-hydroxylase and antihypertensive effect>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is picolinate derivative antihypertensive dopamine hydroxylase; fusarate derivative antihypertensive dopamine hydroxylase; copper complexing picolinate derivative antihypertensive.
Twenty-seven substituted picolinic acids and fusaric acids (I and II, resp.; R = various small groups, as well as halogen) were characterized as weak-to-moderately strong acids which form stable Cu(II) complexes in solution and in the solid state. The concentrations required for 50% inhibition of purified bovine adrenal dopamine β-hydroxylase [9013-38-1] were 10-6-10-5M; I were stronger inhibitors than II. The inhibition was noncompetitive with respect to tyramine but was transitional between competitive and noncompetitive with respect to ascorbic acid. The mechanism of enzyme inhibition could not be explained solely by a complexing of the enzyme Cu. Most I and II had antihypertensive activity in spontaneously hypertensive rats, but some further increased the blood pressure. No correlation was observed between antihypertensive activity and dopamine β-hydroxylase inhibition.
Pharmazie published new progress about Antihypertensives. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.
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