Wilson, Kenneth J.; Illig, Carl R.; Chen, Jinsheng; Wall, Mark J.; Ballentine, Shelley K.; Des Jarlais, Renee L.; Chen, Yanmin; Schubert, Carsten; Donatelli, Robert; Petrounia, Ioanna; Crysler, Carl S.; Molloy, Christopher J.; Chaikin, Margery A.; Manthey, Carl L.; Player, Mark R.; Tomczuk, Bruce E.; Meegalla, Sanath K. published the artcile< Reducing ion channel activity in a series of 4-heterocyclic arylamide FMS inhibitors>, Application of C19H34O2, the main research area is imidazolecarboxamide cyclohexenylaryl nitrile preparation ion channel activity FMS inhibitor.
A series of saturated and aromatic 4-heterocycles of reduced basicity I (R1 = Ph, 4-H2NC6H4, 2-pyridyl, 2,6-dioxo-4-piperidinyl, 2-oxo-3,4,5,6-tetrahydro-1H-pyrimidin-5-yl, etc.; R2 = H, Me) was prepared and evaluated in an attempt to improve the bioavailability of FMS kinase inhibitors and the cardiovascular safety profile over lead arylamide I (R1 = 4-piperidinyl; R2 = H), which possessed ion channel activity. The resultant compounds retained excellent potency and exhibited diminished ion channel activity.
Bioorganic & Medicinal Chemistry Letters published new progress about Anti-inflammatory agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics