De Coen, Ruben; Vanparijs, Nane; Risseeuw, Martijn D. P.; Lybaert, Lien; Louage, Benoit; De Koker, Stefaan; Kumar, Vimal; Grooten, Johan; Taylor, Leeanne; Ayres, Neil; Van Calenbergh, Serge; Nuhn, Lutz; De Geest, Bruno G. published the artcile< pH-Degradable Mannosylated Nanogels for Dendritic Cell Targeting>, Application of C9H3F5O2, the main research area is dendritic cell targeting mannose receptor mannosylated nanogel pH.
We report on the design of glycosylated nanogels via core-crosslinking of amphiphilic non-water-soluble block copolymers composed of an acetylated glycosylated block and a pentafluorophenyl (PFP) activated ester block prepared by reversible addition-fragmentation (RAFT) polymerization Self-assembly, pH-sensitive core-crosslinking, and removal of remaining PFP esters and protecting groups are achieved in one pot and yield fully hydrated sub-100 nm nanogels. Using cell subsets that exhibit high and low expression of the mannose receptor (MR) under conditions that suppress active endocytosis, we show that mannosylated but not galactosylated nanogels can efficiently target the MR that is expressed on the cell surface of primary dendritic cells (DCs). These nanogels hold promise for immunol. applications involving DCs and macrophage subsets.
Biomacromolecules published new progress about Crosslinking. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Application of C9H3F5O2.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics