Smiley, Shelby B.; Zarrinmayeh, Hamideh; Das, Sudip K.; Pollok, Karen E.; Vannier, Michael W.; Veronesi, Michael C. published the artcile< Novel therapeutics and drug-delivery approaches in the modulation of glioblastoma stem cell resistance>, Reference of 112-63-0, the main research area is review glioblastoma temozolomide stem cell drug delivery nanomedicine; CD44; CD133; CSC; GBM; aptamers; cancer stem cells; glioblastoma; idasanutlin; liposome; nanomedicine; nanoparticle; nestin; paclitaxel; solid-lipid nanoparticle; temozolomide; theranostics.
A review. Glioblastoma (GBM) is a deadly malignancy with a poor prognosis. An important factor contributing to GBM recurrence is high resistance of GBM cancer stem cells (GSCs). While temozolomide (TMZ), has been shown to consistently extend survival, GSCs grow resistant to TMZ through upregulation of DNA damage repair mechanisms and avoidance of apoptosis. Since a single-drug approach has failed to significantly alter prognosis in the past 15 years, unique approaches such as multidrug combination therapy together with distinctive targeted drug-delivery approaches against cancer stem cells are needed. In this review, a rationale for multidrug therapy using a targeted nanotechnol. approach that preferentially target GSCs is proposed with discussion and examples of drugs, nanomedicine delivery systems, and targeting moieties.
Therapeutic Delivery published new progress about Apoptosis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.
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