Nagy, Sandor; Feher, Zsuzsanna; Kisszekelyi, Peter; Huszthy, Peter; Kupai, Jozsef published the artcile< Cinchona derivatives as sustainable and recyclable homogeneous organocatalysts for aza-Markovnikov addition>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is cinchona alkaloid organocatalyst preparation; heterocyclylalkyl ester green preparation regioselective; nitrogen heterocycle vinyl ester aza Markovnikov cinchona alkaloid catalyst.
A new application of cinchona alkaloids as organocatalysts in the synthesis of 1-(N-heterocyclyl)alkyl esters, e.g., I was reported via aza-Markovnikov addition reaction of N-heterocycles to vinyl esters. The synthesis of aza-Markovnikov adducts I possessing valuable biol. activity was thoroughly optimized. By studying the ratio of the starting materials, bases and solvents, this new and efficient protocol was achieved which was performed under mild conditions with a small excess of vinyl ester affording products I with excellent yields and high regioselectivity. This optimization reduced Sheldon’s E-factor of the reaction by 42%. Furthermore, membrane separation for catalyst recycling was assessed to further improve the sustainability of the synthesis.
New Journal of Chemistry published new progress about Addition reaction catalysts. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.
Referemce:
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Ester – an overview | ScienceDirect Topics