Tan, Zhangbin; Jiang, Xiaoli; Zhou, Wenyi; Deng, Bo; Cai, Min; Deng, Suihui; Xu, Youcai; Ding, Wenjun; Chen, Guanghong; Chen, Ruixue; Zhang, Shuangwei; Zhou, Yingchun; Liu, Bin; Zhang, Jingzhi published the artcile< Taohong siwu decoction attenuates myocardial fibrosis by inhibiting fibrosis proliferation and collagen deposition via TGFBR1 signaling pathway>, Reference of 112-63-0, the main research area is myocardial fibrosis proliferation TGFBR1 signaling pathway; Cell proliferation; Collagen deposition; Myocardial fibrosis after myocardial infarction; TGFBR1; Taohong siwu decoction.
The purpose of current study was to explore the potential mechanism action and anti-myocardial fibrosis effects of treatment with THSWD in vivo and in vitro. Mouse underwent ligation of coronary artery to induce MI and divided equally into the sham group, model group and THSWD treatment groups. After 4 wk, the effects of THSWD treatment on cardiac function were estimated by echocardiog. HE staining was used to detect the pathol. changes and Masson trichrome staining was used to estimate tissue fibrosis. To further explore the regulatory mol. mechanisms of THSWD, transcriptome anal. was performed. Treatment with THSWD significantly decreased myocardial fibrosis and recovered cardiac function in the post-MI mouse. The transcriptomics data imply that the TGF-β pathway might be a target in the anti-fibrosis effect of THSWD. THSWD inhibits TGF-β1-induced proliferation of primary cardiac fibroblasts. THSWD decreased collagen expression and TGFBR1 and Smad2/3 phosphorylation. Moreover, the inhibitory effect of THSWD on CFs proliferation and collagen deposition, as well as TGFBR1 signaling pathway-associated proteins expression was partially abrogated by overexpression of TGFBR1. Collectively, the results implicate that THSWD attenuates myocardial fibrosis by inhibiting fibrosis proliferation and collagen deposition via inhibiting TGFBR1, and might be a potential therapeutic agent for treatment of myocardial fibrosis post-MI.
Journal of Ethnopharmacology published new progress about Adenoviral vectors. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.
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