Zhang, Yingchun; Wu, Xiaoyi; Wang, Xinhui; Zeng, Yue; Liao, Yixuan; Zhang, Ruizhi; Zhai, Fuqiang; Zeng, Zhongliang published the artcile< Grey relational analysis combined with network pharmacology to identify antioxidant components and uncover its mechanism from Moutan Cortex>, COA of Formula: C19H34O2, the main research area is antioxidant gray relational analysis network pharmacol paeonol paeonia suffruticosa; antioxidant; grey relational analysis; network pharmacology; paeonia suffruticosa andr; paeonol.
The present study determines the potential antioxidants in Moutan Cortex (MC) and predicts its targets of anti-oxidative activities. The quant. anal. and the free radical scavenging assays were conducted to detect the main components in MC and assess its anti-oxidant activities. The gray relational anal. and the network pharmacol. approach were employed to predict its key components and targets of anti-oxidant activities. Six main constitutes in MCs were quantified by high performance liquid chromatog. (HPLC) and its anti-oxidant activities were evaluated by DPPH and ABTS free radical scavenging methods. Then gray relational anal. was employed to predict the key components acting on anti-oxidative activity based on the chem-bio results. The predicted components and its mechanisms on anti-oxidation were uncovered by network pharmacol. approach and cell test, resp. The content of paeonol and paeoniflorin accounts for more than 80% the whole content of detected components. However, the two main ingredients showed a great variety among MCs. The antioxidant capacities of MCs also showed a great discrepancy based on DPPH and ABTS methods. The key components acting on anti-oxidation were identified to be paeonol, gallic acid and benzoylpaeoniflorin, and their potential therapeutic targets were predicted and verified, resp. The present results reveal that MC has a significant antioxidant activity and the compounds of paeonol, gallic acid and benzoylpaeoniflorin could be considered as the promising antioxidant candidates with the property of suppressing oxidative stress and apoptosis.
Frontiers in Pharmacology published new progress about Albumins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.
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