Yuan, Tie-Jun; Xu, Xue-Han; Zhou, Nan; Yan, Ge; Gu, Ting-Wei; Peng, Li-Hua published the artcile< Phytochemicals as new therapeutic candidates simultaneously stimulate proliferation and counteract senescence of stem cells>, HPLC of Formula: 112-63-0, the main research area is phytochem antioxidant Wntbeta catenin signaling stem cell senescence; Molecular mechanism; Phytochemicals; Proliferation; Senescence; Stem cells.
Mesenchymal stem cells (MSCs) are promising candidates for regenerative therapy. However, the research and clin. application of MSCs are greatly hindered by the limited cells proliferation and replicative senescence. Therapeutic agents that can both enhance the proliferative ability and decrease the replicative senescence of MSCs are greatly needed, however, not been reported yet. Herein, for the first time, we identified 11 natural compounds from medicinal plants with both excellent proliferative and anti-senescence abilities in MSCs. The qPCR anal. indicated underlying mechanisms associated with fibroblast growth factor, transforming growth factor, Wnt/beta-catenin and leukemia-induced factor in proliferation; the reactive oxygen species production, mitochondrial dysfunction autophagy and proteostasis are involved in cells senescence-related mechanism. Phytochems. are demonstrated as novel therapeutic candidates with promising effects in both stimulating proliferation and retarding replicative senescence of stem cells with high safety.
Biomedicine & Pharmacotherapy published new progress about AMP-activated protein kinase activators. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics