Xu, Jing; Su, Guannan; Huang, Xinyue; Chang, Rui; Chen, Zhijun; Ye, Zi; Cao, Qingfeng; Kijlstra, Aize; Yang, Peizeng published the artcile< Metabolomic analysis of aqueous humor identifies aberrant amino acid and fatty acid metabolism in Vogt-Koyanagi-Harada and Behcet′s disease>, Category: esters-buliding-blocks, the main research area is Behcet disease metabolomic analysis fatty acid metabolism; Behcet’s disease; Vogt-Koyanagi-Harada disease; amino acids; fatty acids; metabolomics; pathway.
To investigate aqueous metabolic profiles in Vogt-Koyanagi-Harada (VKH) and Behcet′s disease (BD), we applied ultra-high-performance liquid chromatog. equipped with quadrupole time-of flight mass spectrometry in aqueous humor samples collected from these patients and controls. Metabolite levels in these three groups were analyzed by univariate logistic regression. The differential metabolites were subjected to subsequent pathway anal. by MetaboAnalyst. The results showed that both partial-least squares discrimination anal. and hierarchical clustering anal. showed specific aqueous metabolite profiles when comparing VKH, BD, and controls. There were 28 differential metabolites in VKH compared to controls and 29 differential metabolites in BD compared to controls. Amino acids and fatty acids were the two most abundant categories of differential metabolites. Furthermore, pathway enrichment anal. identified several perturbed pathways, including pantothenate and CoA biosynthesis when comparing VKH with the control group, and D-arginine and D-ornithine metabolism and phenylalanine metabolism when comparing BD with the control group. Aminoacyl-tRNA biosynthesis was altered in both VKH and BD when compared to controls. Our findings suggest that amino acids metabolism as well as two fatty acids, palmitic acid and oleic acid, may be involved in the pathogenesis of BD and VKH.
Frontiers in Immunology published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.
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