Lopez, Rosana; Giorgi, M. Eugenia; Melgarejo, Linda Toro; Ducrey, Ivana; Balouz, Virginia; Gonzalez-Salas, Diego; Camara, Maria de los Milagros; Buscaglia, Carlos A.; de Lederkremer, Rosa M.; Marino, Carla published the artcile< Synthesis and characterization of α-D-Galp-(1→3)-β-D-Galp epitope-containing neoglycoconjugates for chagas disease serodiagnosis>, Reference of 112-63-0, the main research area is galactooligosaccharide epitope neoglycoconjugate preparation chagas disease serodiagnosis; Anti α-Gal; Neoglycoconjugate; Squarate conjugation method; Trypanosoma cruzi.
The immunodominant epitope α-D-Galp-(1→3)-β-D-Galp-(1→4)-D-GlcNAc, expressed in the mucins of the infective trypomastigote stage of Trypanosoma cruzi has been proposed for multiple clin. applications, from serodiagnosis of protozoan caused diseases to xenotransplantation or cancer vaccinol. It was previously shown that the analog trisaccharide, with glucose in the reducing end instead of GlcNAc, was as efficient as the natural trisaccharide for recognition of chagasic antibodies. Here we describe the synthesis of α-D-Galp-(1→3)-β-D-Galp-(1→4)-D-Glcp functionalized as the 6-aminohexyl glycoside and its conjugation to BSA using the squarate method. The conjugate of 6-aminohexyl α-D-Galp-(1→3)-β-D-Galp was also prepared Both neoglycoconjugates were recognized by serum samples of Trypanosoma cruzi-infected individuals and thus, are promising tools for the improvement of Chagas disease diagnostic applications.
Carbohydrate Research published new progress about Antibodies and Immunoglobulins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (chagasic). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.
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