Kyosiimire-Lugemwa, Jacqueline; Anywaine, Zacchaeus; Abaasa, Andrew; Levin, Jonathan; Gombe, Ben; Musinguzi, Kenneth; Kaleebu, Pontiano; Grosskurth, Heiner; Munderi, Paula; Pala, Pietro published the artcile< Effect of stopping cotrimoxazole preventive thrapy on microbial translocation and inflmmatory markers among human immunodefiiency virus-infected ugandan adults on antiretroviral thrapy: th COSTOP trial immunology substudy>, HPLC of Formula: 112-63-0, the main research area is cotrimoxazole lamivudine antibiotic antiretroviral agent adult inflammation HIV infection; ART; HIV-1; cotrimoxazole preventive therapy; immune activation; inflammation; microbial translocation.
Background. Cotrimoxazole preventive therapy (CPT) in human immunodeficiency virus (HIV) infection is a World Health Organization-recommended standard of care in resource-limited settings, but the mechanism of CPT’s beneficial effects is unclear. The COSTOP trial (ISRCTN44723643) evaluated the noninferiority of discontinuing CPT in stabilized patients on antiretroviral therapy. The COSTOP immunol. substudy was conducted on a subset of COSTOP participants randomized to continue CPT (n = 86) or discontinue CPT (placebo, n = 86) as daily treatment for 1 yr. Methods. We evaluated whether CPT reduces microbial translocation, indicated by the presence of bacterial lipopolysaccharide (LPS) and LPS control factors such as soluble CD14 (sCD14) and endotoxin core antibody (EndoCAb IgM [IgM]) in plasma. Intestinal barrier damage as indicated by plasma intestinal fatty acid binding protein (IFABP), T-cell activation, and the inflammatory markers C-reactive protein (CRP), interleukin 6 (IL-6), and tumor necrosis factor a (TNF-α) were also evaluated. Results. We found no significant change in markers of microbial translocation (LPS, IFABP, sCD14, and T-cell activation), with decreased EndoCAb IgM. There was significant increase in inflammation markers (CRP and IL-6) aftr stopping CPT compared to those who continued CPT. Conclusions. These results add to the evidence of immunol. benefits of CPT among HIV-infected populations in resourcelimited settings. However, no evidence of reducing microbial translocation was observed
Journal of Infectious Diseases published new progress about Adult, mammalian. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.
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