《One-step Conversion of Amides and Esters to Acid Chlorides with PCl3》 was written by Li, Fangshao; Wu, Xiaofang; Guo, Fengzhe; Tang, Zi-Long; Xiao, Jing. Synthetic Route of C8H7FO2 And the article was included in European Journal of Organic Chemistry in 2021. The article conveys some information:
A general and efficient iodine-promoted chlorination of amides RC(O)NR1R2 [R = Ph, 4-MeC6H4, 4-FC6H4, etc.; R1 = R2 = Me, n-Bu; R1 = H, Me, Ph; R3 = Ph] and esters RC(O)OMe [R = Ph, 4-MeC6H4, 4-BrC6H4, etc.] with phosphorus trichloride was described. For the first time various inactivated amides including secondary and tertiary amides were directly converted to the corresponding acid chlorides in one-step. The substrate scope of Me esters including aromatic and aliphatic esters was also explored under this system. This method was simple, scalable and wide in scope, which provided an approach to preparation of these acid chlorides. In the experimental materials used by the author, we found Methyl 4-fluorobenzoate(cas: 403-33-8Synthetic Route of C8H7FO2)
Methyl 4-fluorobenzoate(cas: 403-33-8) is an organic fluorinated building block used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of Blonanserin.Synthetic Route of C8H7FO2
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics