In 2022,Wang, Fei; Nishimoto, Yoshihiro; Yasuda, Makoto published an article in Angewandte Chemie, International Edition. The title of the article was 《Lewis Acid-Catalyzed Diastereoselective C-C Bond Insertion of Diazo Esters into Secondary Benzylic Halides for the Synthesis of α,β-Diaryl-β-haloesters》.Related Products of 609-14-3 The author mentioned the following in the article:
A formal carbon-carbon (C-C) bond insertion via the reaction of secondary benzylic halides (fluorides, chlorides, and bromides) with α-diazo esters catalyzed by Lewis acid catalysts was reported. Secondary benzylic halides underwent elongation to afford α,β-diaryl-β-haloesters diastereoselectively. D. functional theory calculation revealed that the present formal C-C bond insertion was the result of Lewis acid-promoted cleavage and the re-formation of a carbon-halogen bond and that the aryl-migration step determined the diastereoselectivity. Various diarylmethyl halides and α-diazo esters were applicable to this reaction system. In addition, ring expansion in cyclic benzylic chlorides was accomplished. In addition to this study using Ethyl 2-methyl-3-oxobutanoate, there are many other studies that have used Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Related Products of 609-14-3) was used in this study.
Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Related Products of 609-14-3
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics