Ramakrishna, Kankanala; Biswas, Jyoti Prasad; Jana, Sadhan; Achar, Tapas Kumar; Porey, Sandip; Maiti, Debabrata published the artcile< Coordination Assisted Distal C-H Alkylation of Fused Heterocycles>, Application of C19H34O2, the main research area is oxoalkylquinoline regioselective preparation; oxoalkylthiazole benzothiazole benzoxazole regioselective preparation; quinoline allyl alc regioselective alkylation palladium catalyst; C−H activation; alkylation; bifunctional; heterocycles; non-covalent.
Distal C-H bond functionalization of heterocycles remained extremely challenging with covalently attached directing groups (DG). Lack of proper site for DG attachment and inherent catalyst poisoning by heterocycles demand alternate routes for site selective functionalization of their distal C-H bonds. Utilizing non-productive coordinating property to hold the heterocycle into the cavity of a template system in a host-guest manner, we report distal C-H alkylation (C-5 of quinoline and thiazole, C-7 of benzothiazole and benzoxazole) of heterocycles. Upon complexation with heterocyclic substrate, nitrile DG in template directs the metal catalyst towards close vicinity of the specific distal C-H bond of the heterocycles. Our hypothesized pathway has been supported by various X-ray crystallog. characterized intermediates.
Angewandte Chemie, International Edition published new progress about Alkylation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics