Dhanusha, G.; Sujith, S.; Nisha, Ar; Aathira, Kk; Haima, Js published the artcile< Cytotoxic and antiproliferative potential of methanolic extracts of Asparagus racemosus in MDAMB231 cells>, SDS of cas: 112-63-0, the main research area is cytotoxic antiproliferative potential methanolic extract Asparagus racemosus.
The present study was carried out to evaluate the cytotoxic and antiproliferative activity of methanolic extract of Asparagus racemosus in MDAB-231 cells. The qual. phytochem. anal. of the extract revealed the presence of steroids, alkaloids, flavonoids, glycosides, saponins and diterpenes. MDAMB-231 cells were maintained in RPMI media containing 10 per cent serum and 1 per cent antibiotic and antimycotic solution The cells were harvested and seeded to 96 well plate at 5 x 103 cells/mL, incubated for 24 h at 37°C with 5 per cent CO2. The cells were treated with 160, 80, 40, 20 and 10μg/mL of the extract for 24 h and viability was accessed using MTT Assay. Also cells were plated in 6 well plates at concentrations 3 x 105 cells/mL and exposed to 80, 40, 20 and 10μg/mL of the extract of Asparagus racemosus for acridine orange ethidium bromide (AO/EB) staining. There was a dose dependent decrease in viability of cells exposed to methanolic extracts of Asparagus racemosus with a viability of 15.55 ± 0.193 per cent for cells treated with 160μg/mL. The IC50 was found to be 91.36 ± 0.87μg/mL. The AO/EB staining revealed that most of the cells were dead in extract treated with 80μg/mL where more than 90 per cent of cells were live when treated with 10μg/mL of the extract
Pharma Innovation published new progress about Alkaloids Role: ANT (Analyte), ANST (Analytical Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.
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