Rout, Deeptimayee; Dash, Umesh Chandra; Kanhar, Satish; Swain, Sandeep Kumar; Sahoo, Atish Kumar published the artcile< Homalium zeylanicum attenuates streptozotocin-induced hyperglycemia and cellular stress in experimental rats via attenuation of oxidative stress imparts inflammation>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Homalium hyperglycemia leaf oxidative stress inflammation; 8-OHdG; CRP; Homalium zeylanicum; TNF-α; α-amylase; α-glucosidase.
Homalium zeylanicum (Gardner) Benth (Salicaceae) leaves are being used as folklore medicine to treat diabetes by the local folk of Andhra Pradesh, India. The medicinal claim of this plant with hypoglycemic effects was initially studied by the authors. Antioxidant activities of the hydroalc. fraction of leaves of H. zeylanicum leaves (HAHZL) were pos. correlated with phenols and flavonoids contents. Based on the previous findings, addnl. research is needed to examine the efficacy of using HAHZL to treat hyperglycemia. We therefore investigated in vitro and in vivo glycemic response of HAHZL, and evaluation of possible mechanism of bioactive mols. in mitigating streptozotocin-induced cellular stress in exptl. rats via attenuation of oxidative stress imparts inflammation. GC-MS/MS anal. of HAHZL was carried out to identify bioactive constituents. In vitro antidiabetic (α-glucosidase, α-amylase) and anti-inflammatory activities were investigated. HFD/low-STZ-prompted diabetic Wistar rats were administered with HAHZL (300 and 400 mg/kg; oral) for 28 days. Blood serum, oxidative stress, inflammation, DNA damage, and antidiabetic markers of pancreas and liver were determined Histopathol. studies of liver and pancreas were performed to assess the protective role of HAHZL. GC-MS/MS study revealed 7 bioactive compounds e.g., Phenol, 4-ethenyl-, acetate (28.68%), hydroquinone (9.10%), n-hexadecanoic acid (0.55%), phytol (0.57%), arbutin (17.65%), Vitamin E (1.04%), β-Sitosterol (1.54%) which possess antioxidant, anti-inflammatory and anti-diabetic activities. HAHZL showed significant in vitro glycemic response as evidenced by the inhibition of α-amylase, and α-glucosidase activities. Lineweaver-Burk plot revealed that HAHZL exhibited competitive and mixed competitive inhibition towards α-amylase and α-glucosidase, resp. HAHZL at 400 mg/kg modulated the pathophysiol. associated with HFD/STZ-induced type2 diabetes mellitus and significantly (p < 0.001) improved antihyperglycemic (SG, SI, HOMA-IR, and HbA1C), antidyslipidemic (TC, HDL-C, LDL-C, and TG), antioxidative (MDA, SOD, CAT, GSH, and 8-OHdG) and anti-inflammatory (TNF-α, and CRP) markers in serum, pancreas and liver. In vitro and in vivo test results were corroborated by the improvement of pancreatic and hepatic tissue architecture in diabetic rats. HAHZL bearing bioactive components phenol, 4-ethenyl-,acetate, hydroquinone, n-hexadecanoic acid, arbutin, phytol, vitamin E and β-sitosterol balanced glycemic level by normalizing the levels of glycemic indexes, lipid profile, pancreas and liver functional markers in STZ-induced T2DM rats. Journal of Ethnopharmacology published new progress about Anti-inflammatory agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.
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