Khandazhinskaya, Anastasia; Matyugina, Elena; Novikov, Mikhail published the artcile< Uracil derivatives as non-nucleoside inhibitors of viral infections>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is uracil nucleoside inhibitor viral infection.
Heterocyclic bases as a part of nucleosides and nucleotides are important components of DNA and RNA, and in addition, they take part in a huge number of key metabolic processes, as cofactors or regulators of hundreds of reactions of various types.1 In this regard, any modification of the nucleic base can have a significant effect on the recognition and inhibition of the corresponding enzymes, and, thus, on the spectrum of its activity.1-3 At the moment, analogs and derivatives of nucleic acid components (NA) are important elements of anticancer,1,2,4 antibacterial,5,6 antifungal7,8 and antiviral therapies.1-3,9,10 The antiviral activity of pyrimidine base derivatives has been known since 1963, when it was shown that 20-deoxy-5-iodocytidine inhibits the development of herpesvirus infection.11 Pyrimidine-containing nucleoside analogs became the first drugs for the treatment of infection caused by human immunodeficiency virus type 1 (HIV-1) and are still used in therapy. Zidovudine,12 stavudine,13 lamivudine14,15 and emtricitabine16 are nucleoside inhibitors of HIV-1 reverse transcriptase (NRTI HIV-1). Pyrimidinecontaining analogs of NA components are widely used to treat infections caused by viruses of the herpes group, in particular: brivudine against varicella-zoster virus17 and cidofovir against cytomegalovirus.18 The main mechanism of the antiviral activity of NRTI is intracellular phosphorylation to the corresponding triphosphorylated nucleoside analogs, which then act as
Annual Reports in Medicinal Chemistry published new progress about Antibacterial agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics