Kim, Seok-In; Chu, Feixia; Dueno, Eric E.; Jung, Kyung Woon published the artcile< Alkyl carbonates: efficient three component coupling of aliphatic alcohols, CO2, and alkyl halides in the presence of Cs2CO3>, HPLC of Formula: 617-55-0, the main research area is alkyl carbonate preparation; coupling aliphatic alc carbon dioxide halide; cesium coupling alc carbon dioxide halide.
A three-way coupling was performed using alcs., e.g., Ph(CH2)4OH, CO2, halides, e.g., n-BuBr, leading to the exclusive preparation of mixed alkyl carbonates, where the use of cesium bases was crucial due to the inherently enhanced nucleophilicities of the corresponding cesium alkoxides generated in situ from various aliphatic alcs. Primary and secondary alcs. were easily incorporated into CO2, which then reacted with with various halides including secondary bromides, which are usually resistant to alkylations due to eliminations. The procedures discussed were mild enough to avoid side reactions such as hydrolysis and transesterification, common in various O-alkylation methods in the presence of esters or the equivalent Therefore, chiral substrates encompassing α-hydroxy esters, susceptible to racemization, were also durable under the developed conditions.
Journal of Organic Chemistry published new progress about Aliphatic alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, HPLC of Formula: 617-55-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics