He, Linhua’s team published research in Zhongguo Yiyao Gongye Zazhi in 2001-10-31 | 112-63-0

Zhongguo Yiyao Gongye Zazhi published new progress about Protozoacides. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

He, Linhua; Mei, Yukui; Peng, Zhulun published the artcile< Synthesis of diclazuril>, Quality Control of 112-63-0, the main research area is diclazuril preparation protozoacide.

The protozoacide Diclazuril was synthesized by substituting 3,4,5-trichloronitrobenzene with 4-chlorophenylacetonitrile in the presence of NaOH, reducing with Fe/NH4Cl, diazotizing with NaNO2/HCl and adding with Et cyanoacetylcarbamate to obtain Et [2-[4-(4-chlorophenylcyanomethyl)-3,5-dichlorophenylhydrazo]-2-cyanoacetyl]carbamate, cyclizing intramolecularly in acetic acid in the presence of KOAc under refluxing for 2 h, and hydrolyzing and decarboxylating with 36% HCl and mercaptoacetic acid under refluxing for 8 h, etc.

Zhongguo Yiyao Gongye Zazhi published new progress about Protozoacides. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics