In 2005,Vickerstaffe, Emma; Warrington, Brian H.; Ladlow, Mark; Ley, Steven V. published 《A Highly Automated, Polymer-Assisted Strategy for the Preparation of 2-Alkylthiobenzimidazoles and N,N’-Dialkylbenzimidazolin-2-ones》.Journal of Combinatorial Chemistry published the findings.Quality Control of Methyl 4-fluoro-3-nitrobenzoate The information in the text is summarized as follows:
A multistep, polymer-assisted solution phase strategy for the highly automated (auto-PASP) synthesis of 2-alkylthiobenzimidazole I [R1 = n-Pr, n-Bu, Me2CHCH2, PhCH2CH2, cyclopentyl, Et2CH, etc.; R2 = PhCH2, EtO2CCH2, 3,5-(MeO)2C6H3CH2, (5-methylisoxazol-3-yl)methyl, etc.] and N,N’-dialkylbenzimidazolin-2-one II libraries is presented. The approach incorporates in-line purification techniques to afford library products directly with high purities and is exemplified by the preparation of a 96-member 2-alkylthiobenzimidazole I library and a 72-member N,N’-dialkylbenzimidazolin-2-one II library.Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9Quality Control of Methyl 4-fluoro-3-nitrobenzoate) was used in this study.
Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9) belongs to methyl benzoate. Methyl benzoate reacts at both the ring and the ester, depending on the substrate. Electrophiles attack the ring, illustrated by acid-catalysed nitration with nitric acid to give methyl 3-nitrobenzoate.Quality Control of Methyl 4-fluoro-3-nitrobenzoateMethyl 4-fluoro-3-nitrobenzoate is used to prepare dimethyl 3-nitro-3′,4-oxydibenzoate by reacting with 3-hydroxy-benzoic acid methyl ester.
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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics