In 2022,Go, Su Yong; Chung, Hyunho; Shin, Samuel Jaeho; An, Sohee; Youn, Ju Hyun; Im, Tae Yeong; Kim, Ji Yong; Chung, Taek Dong; Lee, Hong Geun published an article in Journal of the American Chemical Society. The title of the article was 《A Unified Synthetic Strategy to Introduce Heteroatoms via Electrochemical Functionalization of Alkyl Organoboron Reagents》.COA of Formula: C5H11NO2 The author mentioned the following in the article:
Based on systematic electrochem. anal., an integrated synthetic platform of C(sp3)-based organoboron compounds was established for the introduction of heteroatoms. The electrochem. mediated bond-forming strategy is highly effective for the functionalization of sp3-hybridized C atoms with significant steric hindrance. Also, virtually all the nonmetallic heteroatoms could be used as reaction partners using one unified protocol. The observed reactivity stems from the two consecutive single-electron oxidations of the substrate, which eventually generates an extremely reactive carbocation as the key intermediate. The detailed reaction profile could be elucidated through multifaceted electrochem. studies. Ultimately, a new dimension in the activation strategies for organoboron compounds was accomplished through the electrochem. driven reaction development. After reading the article, we found that the author used tert-Butyl carbamate(cas: 4248-19-5COA of Formula: C5H11NO2)
tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.COA of Formula: C5H11NO2
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics