《Surfactant Micelles Enable Metal-Free Spirocyclization of Keto-Ynamides and Access to Aza-Spiro Scaffolds in Aqueous Media》 was written by Beltran, Frederic; Vela-Gonzalez, Andrea V.; Knaub, Tatiana; Schmutz, Marc; Krafft, Marie Pierre; Miesch, Laurence. SDS of cas: 623-47-2This research focused onynamide keto sufactant micelle base spirocyclization; aza spirocycle preparation. The article conveys some information:
Micellar solutions of cetyltrimethylammonium bromide (CTAB) surfactant allow the spirocyclization of keto-ynamides in an aqueous medium without recourse to transition-metal catalysis, enabling access in water to naturally occurring aza-spiro compounds with potential in drug discovery. The reaction was monitored by dynamic light scattering (DLS) and cryogenic transmission electron microscopy (cryo-TEM), which determined the morphol. and change in size of the micelles before and after incorporation of the substrate and achievement of 5-endo-dig cyclization inside the micelles.Ethyl propiolate(cas: 623-47-2SDS of cas: 623-47-2) was used in this study.
Ethyl propiolate(cas: 623-47-2) is a clear colorless to pale yellow liquid that is soluble in ethanol, ether and chloroform. It an important organic chemical raw material and pharmaceutical intermediate. Ethyl propargylate is obtained by oxidation of propargyl alcohol to propargylic acid followed by esterification.SDS of cas: 623-47-2
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics