Application of 30414-53-0On May 12, 2021 ,《Rapid broad spectrum detection of carbapenemases with a dual fluorogenic-colorimetric probe》 appeared in Journal of the American Chemical Society. The author of the article were Ma, Chi-Wang; Ng, Kenneth King-Hei; Yam, Bill Hin-Cheung; Ho, Pak-Leung; Kao, Richard Yi-Tsun; Yang, Dan. The article conveys some information:
Carbapenems stand as one of the last-resort antibiotics; however, their efficacy is threatened by the rising number and rapid spread of carbapenemases. Effective antimicrobial stewardship thus calls for rapid tests for these enzymes to aid appropriate prescription and infection control. Herein, we report the first effective pan-carbapenemase reporter CARBA-H with a broad scope covering all three Ambler classes. Using a chem. biol. approach, we demonstrated that the absence of the 1β-substituent in the carbapenem core is key to pan-carbapenemase recognition, which led to our rational design and probe development. CARBA-H provides a dual colorimetric-fluorogenic response upon carbapenemase-mediated hydrolysis. A clear visual readout can be obtained within 15 min when tested against a panel of carbapenemase-producing Enterobacteriaceae (CPE) clin. isolates that notably includes OXA-48 and OXA-181-producing strains. Furthermore, CARBA-H can be applied to the detection of carbapemenase activity in CPE-spiked urine samples. The results came from multiple reactions, including the reaction of Methyl 3-oxovalerate(cas: 30414-53-0Application of 30414-53-0)
Methyl 3-oxovalerate(cas: 30414-53-0) belongs to ketone compounds. Ketone compounds have important physiological properties. They are found in several sugars and in compounds for medicinal use, including natural and synthetic steroid hormones. Molecules of the anti-inflammatory agent cortisone contain three ketone groups.Application of 30414-53-0
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