《Chemo- and Enantioselective Oxidative α-Azidation of Carbonyl Compounds》 was published in Angewandte Chemie, International Edition in 2020. These research results belong to Uyanik, Muhammet; Sahara, Naoto; Tsukahara, Mayuko; Hattori, Yuhei; Ishihara, Kazuaki. Synthetic Route of C7H12O3 The article mentions the following:
The authors report high-performance I+/H2O2 catalysis for the oxidative or decarboxylative oxidative α-azidation of carbonyl compounds by using sodium azide under biphasic neutral phase-transfer conditions. To induce higher reactivity especially for the α-azidation of 1,3-dicarbonyl compounds, the authors designed a structurally compact isoindoline-derived quaternary ammonium iodide catalyst bearing electron-withdrawing groups. The nonproductive decomposition pathways of I+/H2O2 catalysis could be suppressed using a catalytic amount of a radical-trapping agent. This oxidative coupling tolerates a variety of functional groups and could be readily applied to the late-stage α-azidation of structurally diverse complex mols. Moreover, the authors achieved the enantioselective α-azidation of 1,3-dicarbonyl compounds as the first successful example of enantioselective intermol. oxidative coupling with a chiral hypoiodite catalyst. In the experimental materials used by the author, we found Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Synthetic Route of C7H12O3)
Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Synthetic Route of C7H12O3
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics