Name: 3-(Methoxycarbonyl)benzoic acidOn September 1, 2019 ,《Design and synthesis of 3-aminophthalazine derivatives and structural analogues as PDE5 inhibitors: anti-allodynic effect against neuropathic pain in a mouse model》 was published in European Journal of Medicinal Chemistry. The article was written by Bollenbach, Maud; Lugnier, Claire; Kremer, Melanie; Salvat, Eric; Megat, Salim; Bihel, Frederic; Bourguignon, Jean-Jacques; Barrot, Michel; Schmitt, Martine. The article contains the following contents:
Herein, a series of aminophthalazine I [R = H, Ph, 1-piperidyl, etc.; R1 = H, CF3; R2 = 3-ClC6H4NH, 4-MeOC6H4CH2NH, Ph(CH2)2NH, etc.] and aminoindazole derivatives II [R3 = H, Cl, CF3; R4 = H, Me, Ph, etc.; R5 = 3-ClC6H4, 4-MeOC6H4CH2, 3-F-4-MeOC6H3CH2, etc.] were synthesized and evaluated for their inhibitory activity toward PDE5. Selectivity profiles towards other PDE1-4 isoenzymes, water solubility and stability in acidic medium of the most potent PDE5 inhibitors were determined and the aminophthalazine I [R = Ph, R1 = CF3, R2 = 4-OMeC6H4CH2NH] and its mimetic compound II [R3 = CF3, R4 = 3-pyridyl, R5 = 4-OMeC6H4CH2NH] were evaluated in comparison to MY 5445 in vivo in a model of neuropathic pain induced by sciatic nerve cuffing in mice (3 and 0.5 mg/kg, i.p. twice a day). Both compounds showed the same efficacy on neuropathic allodynia as MY 5445 and thus produced a significant relief of mech. hypersensitivity after 12 days of treatment. In the experimental materials used by the author, we found 3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0Name: 3-(Methoxycarbonyl)benzoic acid)
3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0) belongs to esters. Esters are more polar than ethers but less polar than alcohols. Name: 3-(Methoxycarbonyl)benzoic acid They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics