Reference of N-tert-ButoxycarbonylhydroxylamineIn 2019 ,《1-Aminopyridinium Ylides as Monodentate Directing Groups for sp3 C-H Bond Functionalization》 appeared in Journal of the American Chemical Society. The author of the article were Le, Ky Khac Anh; Nguyen, Hanh; Daugulis, Olafs. The article conveys some information:
1-Aminopyridinium ylides are efficient directing groups for palladium-catalyzed β-arylation and alkylation of sp3 C-H bonds in carboxylic acid derivatives The efficiency of these directing groups depends on the substitution at the pyridine moiety. The unsubstituted pyridine-derived ylides allow functionalization of primary C-H bonds, while methylene groups are unreactive in the absence of external ligands. 4-Pyrrolidinopyridine-containing ylides are capable of C-H functionalization in acyclic methylene groups in the absence of external ligands, thus rivaling the efficiency of the aminoquinoline directing group. Preliminary mechanistic studies have been performed. A cyclopalladated intermediate has been isolated and characterized by X-ray crystallog., and its reactivity was studied. The experimental process involved the reaction of N-tert-Butoxycarbonylhydroxylamine(cas: 36016-38-3Reference of N-tert-Butoxycarbonylhydroxylamine)
N-tert-Butoxycarbonylhydroxylamine(cas: 36016-38-3) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Reference of N-tert-Butoxycarbonylhydroxylamine
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