Bao, Jiyin; Liu, Haichun; Zhi, Yanle; Yang, Wenqianzi; Zhang, Jiawei; Lu, Tao; Wang, Yue; Lu, Shuai published the artcile< Discovery of benzo[d]oxazole derivatives as the potent type-I FLT3-ITD inhibitors>, Application of C19H34O2, the main research area is phenylamino benzooxazole preparation antitumor activity tyrosine kinase inhibitor SAR; AML; Benzo[d]oxazole; FLT3 inhibitor.
A series of compounds I [R1 = H, Me, F, MeO; R2 = diethylamino, piperidinyl, piperazin-1-yl, etc.; R3 = Ph, pyridin-3-yl, pyridin-4-yl, etc.] were designed and synthesized based on benzo[d]oxazole-2-amine scaffold to discover new potent Fms-like tyrosine kinase 3 inhibitors. During the medicinal chem. works, flexible mol. docking was used to provide design rationale and study the binding modes of the target compounds Through the mixed SAR exploration based on the enzymic and cellular activities, compound I [R1 = MeO; R2 = piperazin-1-yl; R3 = 3-carbamoylphenyl] was identified with potent FLT3-ITD inhibitory (IC50: 0.41 nM) and anti-proliferative (IC50: 0.037μM against MV4-11 cells) activities. And the binding mode of I [R1 = MeO; R2 = piperazin-1-yl; R3 = 3-carbamoylphenyl] with ”DFG-in” FLT3 was simulated by a 20-ns mol. dynamics run, providing some insights into further medicinal chem. efforts toward novel FLT3 inhibitors in AML therapy.
Bioorganic Chemistry published new progress about Acute myeloid leukemia. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics