Hao, Lin; Chen, Shaojin; Xu, Jianfeng; Tiwari, Bhoopendra; Fu, Zhenqian; Li, Tong; Lim, Jieyan; Chi, Yonggui Robin published the artcile< Organocatalytic Activation of Alkylacetic Esters as Enolate Precursors to React with α,β-Unsaturated Imines>, HPLC of Formula: 112-63-0, the main research area is enantioselective organocatalytic NHC catalyzed cycloaddition unsaturated imine alkanoate enolate.
Asym. functionalization of alkylacetic esters and their derivatives is traditionally achieved via preformed enolates with chiral auxiliaries. Catalytic versions of such transformations are attractive but challenging. A direct catalytic activation of simple alkylacetic esters via N-heterocyclic carbene organocatalysts to generate chiral enolate intermediates for highly enantioselective reactions is reported. E.g., chiral NHC-catalyzed cycloaddition of PhCH:CHC(:NTs)Ph with 4-nitrophenyl butanoate in presence of DBU afforded trans-lactam I as the major diastereomer in 99% ee.
Organic Letters published new progress about Carboxylic esters Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics