Brain, C. T.; Chen, A.; Nelson, A.; Tanikkul, N.; Thomas, E. J. published the artcile< An approach to the total synthesis of lankacidins: synthesis of the requisite building blocks>, Recommanded Product: (S)-Dimethyl 2-hydroxysuccinate, the main research area is lankacidin C precursor preparation azetidinone aldehyde sulfone; addition stereoselective cuprate alkyne; aldol condensation Mitsunobu reaction preparation azetidinone.
A strategy for a total synthesis of lankacidin C (I) is outlined and the requisite building blocks synthesized. The azetidinone (II) was prepared from Me but-2-ynoate via a route which features the stereoselective addition of a tributyltin cuprate to the alkyne, an asym. aldol condensation and formation of the azetidinone by an intramol. Mitsunobu reaction. The aldehyde (III) was prepared from di-Me malate and the sulfone (IV) from prop-2-ynol again using asym. aldol reactions as key steps. Syntheses of intermediates II, III, and IV for a projected synthesis of I are described.
Tetrahedron Letters published new progress about Aldol condensation, stereoselective. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Recommanded Product: (S)-Dimethyl 2-hydroxysuccinate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics