Yan, Xue-Long; Chen, Bei-Ling; Yuan, Fang-Yu; Zhu, Qin-Feng; Zhang, Xu; Lin, Yan; Long, Qing-De; Liao, Shang-Gao published the artcile< Six new tigliane diterpenoids with anti-inflammatory activity from Euphorbia kansuensis>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is tigliane diterpenoid isolation antiinflammatory.
Six new tigliane diterpenoids, euphkanoids A – F I [R1 = OH, [(2E,4E,6E)-8-oxoocta-2,4,6-trienoyl]oxy, [(2E,4E,6E,8E)-10-oxodeca-2,4,6,8-tetraenoyl]oxy; R2 = H, acetyl; R3 = H, acetyl, [(9Z,12Z)-octadeca-9,12-dienoyl]], along with 12 known diterpenoids II [R4 = isopropenyl, isopropyl], III [R5 = oxo, hydroxy], IV, V, and VI were isolated from the roots of Euphorbia kansuensis, a traditional Chinese medicinal plant. Their structures were elucidated by spectroscopic anal., ECD calculation and chem. methods. Compounds I [R1 = [(2E,4E,6E)-8-oxoocta-2,4,6-trienoyl]oxy, [(2E,4E,6E,8E)-10-oxodeca-2,4,6,8-tetraenoyl]oxy, 2,4,6,8,10-dodecapentaenoyl; R2 = acetyl; R3 = H] represent the unusual examples of tigliane diterpenoids with a conjugated olefinic aldehyde moiety. I-VI and two hydrolyzed analogs I [R1 = H, OH; R2 = H; R3 = H] were screened for the inhibitory effects on nitric oxide (NO) production induced by lipopolysaccharide (LPS) in RAW264.7 cells. The results showed that I [R1 = [(2E,4E,6E)-8-oxoocta-2,4,6-trienoyl]oxy, [(2E,4E,6E,8E)-10-oxodeca-2,4,6,8-tetraenoyl]oxy, 2,4,6,8,10-dodecapentaenoyl; R2 = acetyl; R3 = H] and VII markedly inhibited NO production with IC50 values in the range of 4.8-11.3μM, which were more active than the pos. control quercetin (IC50 = 12.3μM).
Arabian Journal of Chemistry published new progress about Alcohols Role: PAC (Pharmacological Activity), PUR (Purification or Recovery), THU (Therapeutic Use), BIOL (Biological Study), PREP (Preparation), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.
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