《Cut and sew: benzofuran-ring-opening enabled cyclopentenone ring formation》 was published in Chemical Communications (Cambridge, United Kingdom) in 2020. These research results belong to Wang, Kai; Jiang, Chenghao; Zhang, Zhenming; Han, Chunyu; Wang, Xuewei; Li, Yaping; Chen, Kaiting; Zhao, Junfeng. Application In Synthesis of Ethyl 2-methyl-3-oxobutanoate The article mentions the following:
A facile approach to the fully substituted cyclopentenones involving an unprecedented benzofuran-ring-opening has been described. For example, treatment of dienyl-substituted benzofurans I (R1 = H, 5-Me, 6-O2N, 5,6-benzo, etc.; R2 = CN, MeCO, EtO2C, MeSO2, etc.) with a catalytic amount of TMSOTf in nitromethane afforded the corresponding phenol-substituted indenones II in moderate to good yields and with good diastereoselectivity. The cleavage of a benzofuran endocyclic C2-O bond proceeded smoothly in the absence of any transition metal catalyst or highly reactive organometallic reagent. Such benzofuran-ring-opening is delicately incorporated into an acid-catalyzed cascade process, orchestrating a novel synthetic strategy for complex cyclopentenones. In the experiment, the researchers used many compounds, for example, Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Application In Synthesis of Ethyl 2-methyl-3-oxobutanoate)
Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Application In Synthesis of Ethyl 2-methyl-3-oxobutanoate
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