In 2010,Jakobsche, Charles E.; Choudhary, Amit; Miller, Scott J.; Raines, Ronald T. published 《n → π* Interaction and n)(π Pauli Repulsion Are Antagonistic for Protein Stability》.Journal of the American Chemical Society published the findings.Recommanded Product: Methyl 3-hydroxypropanoate The information in the text is summarized as follows:
In many common protein secondary structures, such as α-, 310, and polyproline II helixes, an n → π* interaction places the adjacent backbone amide carbonyl groups in close proximity to each other. This interaction, which is reminiscent of the Burgi-Dunitz trajectory, involves delocalization of the lone pairs (n) of the oxygen (Oi-1) of a peptide bond over the antibonding orbital (π*) of Ci:Oi of the subsequent peptide bond. Such a proximal arrangement of the amide carbonyl groups should be opposed by the Pauli repulsion between the lone pairs (n) of Oi-1 and the bonding orbital (π) of Ci:Oi. We explored the conformational effects of this Pauli repulsion by employing common peptidomimetics, wherein the n → π* interaction is attenuated while the Pauli repulsion is retained. Our results indicate that this Pauli repulsion prevents the attainment of such proximal arrangement of the carbonyl groups in the absence of the n → π* interaction. This finding indicates that the poor mimicry of the amide bond by many peptidomimetics stems from their inability to partake in the n → π* interaction and emphasizes the quantum-mech. nature of the interaction between adjacent amide carbonyl groups in proteins.Methyl 3-hydroxypropanoate(cas: 6149-41-3Recommanded Product: Methyl 3-hydroxypropanoate) was used in this study.
Methyl 3-hydroxypropanoate(cas: 6149-41-3) belongs to esters with low molecular weight are commonly used as fragrances and found in essential oils and pheromones. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Recommanded Product: Methyl 3-hydroxypropanoate
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