In 2019,Chemical Communications (Cambridge, United Kingdom) included an article by Parmar, Sangeeta; Pawar, Sharad P.; Iyer, Ramkumar; Kalia, Dimpy. Reference of N-tert-Butoxycarbonylhydroxylamine. The article was titled 《Aldehyde-mediated bioconjugation via in situ generated ylides》. The information in the text is summarized as follows:
A tech. simple approach for rapid, high-yielding and site-selective bioconjugation has been developed for both in vitro and cellular applications. This method involves the generation of maleimido-phosphonium ylides via 4-nitrophenol catalysis under physiol. conditions followed by their Wittig reactions with aldehyde-appended biomols. In addition to this study using N-tert-Butoxycarbonylhydroxylamine, there are many other studies that have used N-tert-Butoxycarbonylhydroxylamine(cas: 36016-38-3Reference of N-tert-Butoxycarbonylhydroxylamine) was used in this study.
N-tert-Butoxycarbonylhydroxylamine(cas: 36016-38-3) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Reference of N-tert-Butoxycarbonylhydroxylamine
Referemce:
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