These common heterocyclic compound, 5445-17-0, name is Methyl 2-bromopropanoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C4H7BrO2
Add p-chlorodiphenyl disulfide (0.5 mmol) to a 10 mL reaction tube.Methyl alpha-bromopropionate (1.0 mmol),Zinc powder (2.0 mmol) solvent toluene (2 mL) and dinuclear Schiff base titanium perfluorooctanesulfonic acid complex (X=OSO2C8F17)(0.04 mmol), stirred for 4 h at 25C. Spin dry after the reaction is over.The residue was extracted with ether three times and the filtrate was evaporatedThe crude product was separated by silica gel column chromatography.This gave methyl 2-p-chlorophenylthiopropionate as a colorless oily liquid in a yield of 86%.
The synthetic route of Methyl 2-bromopropanoate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shanxi Medical University; Li Ningbo; Wang Lingxiao; Wang Haojiang; Zhao Wenjie; (13 pag.)CN107722049; (2018); A;,
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