Hao, Zhonglin; Sekkath Veedu, Janeesh published the artcile< Current Strategies for Extensive Stage Small Cell Lung Cancer Beyond First-line Therapy>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is review small cell lung cancer therapy drug combination; Molecular target; Small cell lung cancer; refractory, relapsed; strategy; treatment.
A review. Extensive stage small cell lung cancer carries extremely poor prognosis and adding immune checkpoint inhibitor to platinum etoposide combination in first line only improved outcomes modestly. Once disease recurs, treatment response is only transient in nature. Various strategies that are being explored include dual checkpoint blockade, BiTE and CAR-T cell approaches. Immune checkpoint inhibitors are being combined with PARP inhibitors. Other approaches currently being investigated include liposomal irinotecan and combining known active agents for SCLC in relapsed setting such as newly approved lurbinectedin with doxorubicin, paclitaxel, irinotecan or topotecan with ATR inhibitor (Berzosertib). Temozolomide has also been tested in combination with a Parp inhibitor. New antibody or small mol. drug conjugates are being actively investigated, so is a biomarker based approach. Better understanding of small cell lung cancer disease biol. via high through-put genomic, proteomic and methylation profiling offer glimpse of hope in our efforts to contain this deadly disease. A table of representative mol. targets under investigation is provided in the end.
Clinical Lung Cancer published new progress about Antibody-drug conjugates. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics