Yang, Chengbin; Zhang, Xi; Wang, Yi; Yang, Yongtai; Liu, Xiaofeng; Deng, Mingli; Jia, Yu; Ling, Yun; Meng, Ling-hua; Zhou, Yaming published the artcile< Discovery of a Novel Series of 7-Azaindole Scaffold Derivatives as PI3K Inhibitors with Potent Activity>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is azaindole phosphoinositide kinase inhibitor; 1H-pyrrolo[2,3-b] pyridine; PI3K; PI3K/mTOR; cancer therapy; oncology.
The phosphoinositide 3-kinase (PI3K) inhibitors potently inhibit the signaling pathway of PI3K/AKT/mTOR, which provides a promising new approach for the molecularly targeted cancer therapy. In this work, a novel series of 7-azaindole scaffold derivatives was discovered by the fragment-based growing strategy. The structure-activity relationship profiles identified that the 7-azaindole scaffold derivatives exhibit potent activity against PI3K at mol. and cellular levels as well as cell proliferation in a panel of human tumor cells.
ACS Medicinal Chemistry Letters published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics