Serbanovic, Ana; Branco, Luis C.; Nunes da Ponte, Manuel; Afonso, Carlos A. M. published the artcile< Osmium catalyzed asymmetric dihydroxylation of methyl trans-cinnamate in ionic liquids, followed by supercritical CO2 product recovery>, Related Products of 112-63-0, the main research area is osmium asym dihydroxylation cinnamate ionic liquid supercritical carbon dioxide; taxol side chain osmium dihydroxylation catalyst recycling.
In this work, osmium-catalyzed asym. dihydroxylation (AD) of Me trans-cinnamate was studied. Osmium and chiral ligand catalysts were immobilized in ionic liquid only, without any other reaction solvents, while the recovery of the product was performed by extraction with supercritical CO2, and compared with results obtained by extractions with organic solvents such as hexane and di-Et ether. In supercritical CO2 extraction experiments, optimal extraction pressure was found and ionic liquid chosen, so that the highest reaction yields coupled with lowest osmium content in the crude product can be achieved. Finally, recycle experiments of the same (ionic liquid + catalytic system) mixture were successfully conducted. Application of ionic liquids and supercritical CO2 in osmium catalyzed AD allows for the isolation of the diol basically without contamination with osmium, in high yield and enantiomeric excess, and it makes possible the efficient reuse of ionic liquid solvent and the catalytic system. The stereoselective dihydroxylation of trans-cinnamate gave (αR,βS)-α,β-di(hydroxy)benzenepropanoic acid Me ester.
Journal of Organometallic Chemistry published new progress about Dihydroxylation, stereoselective. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.
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