Zhang, Jingjing; Yang, Jin-Dong; Zheng, Hanliang; Xue, Xiao-Song; Mayr, Herbert; Cheng, Jin-Pei published the artcile< Exploration of the Synthetic Potential of Electrophilic Trifluoromethylthiolating and Difluoromethylthiolating Reagents>, COA of Formula: C19H34O2, the main research area is trifluoromethylsulfenylation difluoromethylsulfenylation reagent electrophilicity; difluoromethylthiolation; electrophilicity; linear free-energy relationships; structure-reactivity relationships; trifluoromethylthiolation.
The electrophilicity parameters (E) of some trifluoromethylthiolating and difluoromethylthiolating reagents were determined by following the kinetics of their reactions with a series of enamines and carbanions with known nucleophilicity parameters (N, sN), using the linear free-energy relationship log k2=sN(N+E). The electrophilic reactivities of these reagents cover a range of 17 orders of magnitude, with Shen and Lu’s reagent (PhSO2)2NSCF3 being the most reactive and Billard’s reagent PhNMeSCF3 being the least reactive electrophile. While the observed electrophilic reactivities (E) of the amido-derived trifluoromethylthiolating reagents correlate well with the calculated Gibbs energies for heterolytic cleavage of the X-SCF3 bonds (Tt+DA), the cumol-derived reagents RCMe2OSCF3 (R = Ph, 2-IC6H4) are more reactive than expected from the thermodn. of the O-S cleavage. The E parameters of the tri/difluoromethylthiolating reagents derived in this work provide an ordering principle for their use in synthesis.
Angewandte Chemie, International Edition published new progress about Carbanions Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics