Fatimawali; Kalalo, Marko Jeremia; Simanjuntak, Siboantua Broolin; Hebber, Tri Andira; Kepel, Billy Johnson; Tallei, Trina Ekawati published the artcile< Immunomodulatory potential of bioactive compounds of betel leaf extract targeting COVID-19 immunological human host proteins: an in silico study>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is betel leaf immunomodulator.
Forests contain nearly all of the natural resources required by humans. Apart from food, the community makes use of forest products for medicinal purposes. Betel (Piper betle) is 1 of the numerous forest plants that thrive in the forests of North Sulawesi. The leaves and fruits are used by indigenous people as anti-inflammatory medications, deodorizing body odors, and for maintaining health. Natural medicine has recently been included in clin. trials as immunomodulators in COVID-19 patients. This study aimed to identify novel immunomodulatory compounds derived from betel leaf for the treatment of COVID-19 symptoms, particularly proinflammatory cytokines (tumor necrosis factor-α, interleukin-1β, interleukin-6, and nuclear factor kappa B). These cytokines are critical in modulating immune responses. Bioactive compounds from betel leaves were extracted and identified using gas chromatog.-mass spectrometry. These compounds were used as ligands for PyRx-based mol. docking. The admetSAR and SwissADME were used to predict ADMET (absorption, distribution, metabolism, excretion, and toxicity) and Lipinski′s rule of 5 parameters of the studied compounds This study discovered that 17 compounds exhibited higher binding energy than the control immunomodulatory agents (β-glucan and thiopurine). Only 1 of the compounds violated Lipinski′s rule of 5. ADMET predictions indicated that the compounds possess favorable and safe pharmacokinetic properties, making them suitable for development as drug candidates. The research findings suggest that bioactive compounds derived from betel leaf may prove beneficial in the treatment of COVID-19, particularly in the context of cytokine storms.
Journal of Applied Pharmaceutical Science published new progress about Anticoronaviral agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.
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