Ma, Ning; Chen, Xing-hua; Zhao, Yan; Kang, Xu; Pan, Shan; Yao, Wen-qing published the artcile< HIV-1 molecular transmission network among sexually transmitted populations in Liaoning Province, China>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is HIV1 sexually transmitted disease mol transmission network China.
In recent years, with the development of mol. epidemiol., mol. transmission networks based on evolutionary theory and sequence anal. have been widely used in research on human immunodeficiency virus (HIV)-1 transmission dynamics and precise intervention for high-risk populations. The HIV-1 mol. transmission network is a new method to study the populations access to the network, the characteristics of clustering, and the characteristics of interconnection in the network. Here, we analyzed the characteristics of the HIV-1 mol. transmission network of sexually transmitted people in Liaoning Province. A study of HIV-infected persons who were sexually transmitted in Liaoning Province from 2003 to 2019. HIV-1 RNA was extracted, amplified and sequenced, and a phylogenetic tree was constructed to determine the subtype using the well matched pol gene region sequence. The gene distance between sequences was calculated, the threshold was determined, and the mol. transmission network was constructed. 109 samples of pol gene region were obtained. The main subtype of HIV-1 was CRF01_AE, followed by B, CRF07_BC, etc. 12.8% of them were resistant to HIV. At the threshold of 0.55 gene distance, 60.6% of them entered the HIV-1 mol. transmission network. Workers, sample source voluntary counseling and testing, other testing, subtype B and drug resistance are the factors influencing the access to HIV-1 mol. transmission network. The subtype of CRF01_AE formed 6 clusters in the mol. transmission network. In the network, the difference of connection degree between different subtypes was statistically significant. The three subtypes CRF01_AE, CRF07_BC and B that enter the mol. transmission network do not have interconnections, and they form clusters with each other. It shows that the risk of transmission among the three subtypes is less than the risk of transmission within each subtype. The factors affecting HIV-1 entry into the mol. transmission network were occupation, sample source, genotype and drug resistance. The L33F mutation at the HIV-1 resistance mutation site constitutes the interconnection in the largest transmission cluster in the network. The epidemiol. characteristics of HIV-infected persons in each mol. transmission cluster show that 97% of the study subjects come from the same area and have a certain spatial aggregation. Constructing a mol. transmission network and conducting long-term monitoring, while taking targeted measures to block the spread of HIV can achieve precise prevention and control.
Medicine (Philadelphia, PA, United States) published new progress about Animal gene Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (pol). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.
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