Nunez-Mojica, Guillermo; Rivas-Galindo, Veronica M.; Garza-Gonzalez, Elvira; Miranda, Luis D.; Romo-Perez, Adriana; Pagniez, Fabrice; Picot, Carine; Le Pape, Patrice; Bazin, Marc-Antoine; Marchand, Pascal; Camacho-Corona, Maria del Rayo published the artcile< Antimicrobial and antileishmanial activities of extracts and some constituents from the leaves of Solanum chrysotrichum Schldl>, Related Products of 112-63-0, the main research area is Solanum leaves antimicrobial antileishmanial.
Abstract: Three organic extracts were prepared from the leaves of Solanum chrysotrichum Schldl. From the methanol extract were isolated two new steroidal saponins (1, 2), and three known compounds (3, 4, and 5). The new saponins were elucidated as 6-α-O-α-L-rhamnopyranosyl-(1 → 3)-β-D-quinovopyranosyl-(25S)-5α-spirostan-3β-ol (1) and 6-α-O-α-L-rhamnopyranosyl-(1 → 3)-β-D-quinovopyranosyl-(23R,25S)-5α-spirostan-3β,23β-ol (2). The structural elucidation of compounds was performed by anal. of 1D and 2D NMR spectral data and HRMS. Antibacterial activity was displayed by the hexane and CH2Cl2 extracts against carbapenem-resistant Pseudomonas aeruginosa (MIC = 250 μg/mL) and carbapenem-resistant Acinetobacter baumannii (MIC = 125 μg/mL). The known saponin (3) was the only compound active against bacteria, showing activity against all the gram-pos. bacteria (MIC = 12.5 μg/mL). Antitubercular activity was observed only for the hexane extract (MIC = 250 μg/mL). The antifungal and antileishmanial activities were determined for the steroidal saponins, but they were devoid of antifungal activity at the concentrations tested. Antileishmanial activity was shown only by the saponin (1) (IC50: 21.64 ± 1.21 μg/mL). [graphic not available: see fulltext]
Medicinal Chemistry Research published new progress about Acinetobacter baumannii (carbapenem-resistant). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.
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