Whitehead, Daniel C.; Fhaner, Matthew; Borhan, Babak published the artcile< A peptide bromoiodinane approach for asymmetric bromolactonization>, SDS of cas: 112-63-0, the main research area is bromomethylphenyltetrahydrofuranone enantioselective preparation; phenylpentenoic acid asym bromolactonization iodoarylpeptide catalyst; iodoarylpeptide solid phase preparation bromolactonization.
A series of 37 peptides containing an iodo-aryl amide active site were generated by means of both solid phase and conventional synthesis. These peptides were screened for asym. induction in the bromolactonization of 4-phenyl-4-pentenoic acid based on the generation of chiral bromoiodinane bromenium sources. The study culminated in the discovery of a tri-peptide iodo-aryl amide that effected the desired bromolactonization in quant. conversion with 24% ee. The experiments disclosed herein provided valuable insight that ultimately facilitated the development of more synthetically useful enantioselective halocyclization methodol.
Tetrahedron Letters published new progress about Enantioselective synthesis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics