Wu, Xiaoting; Qi, Xiaoyi; Wang, Jing; Zhang, Yunying; Xiao, Yanwei; Tu, Caixia; Wang, Aoxue published the artcile< Paeoniflorin attenuates the allergic contact dermatitis response via inhibiting the IFN-γ production and the NF-κB/IκBα signaling pathway in T lymphocytes>, Computed Properties of 112-63-0, the main research area is paeoniflorin attenuate allergic dermatitis inhibiting IFNG NFkB IkBa signaling; Allergic contact dermatitis; Mice; NF-κB signaling pathway; Paeoniflorin; T lymphocytes.
Paeoniflorin (PF) has been demonstrated to have an anti-allergic and anti-inflammatory effect in the treatment of allergic contact dermatitis (ACD). However, its clin. application is hampered by the lacking of comprehensive mech. explanation. This research aimed to study the effect of PF on the proliferation, apoptosis and cytokines secretion as well as the expression of nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathways of T lymphocytes activation in vitro and in vivo. We found that PF depressed human T lymphocytes activation via inhibition of interferon-gamma (IFN-γ) production and NF-κB/IκBα and p38 MAPK signaling pathway in vitro, also PF could attenuate such ACD responses by inhibiting the production of IFN-γ and NF-κB/IκBα pathway in T lymphocytes of ACD mouse model, suggesting that PF might be useful for the treatment of T cell-mediated allergic inflammatory disorders such as ACD. This would make PF a promising T cell-targeted drug candidate for further study because of its immunosuppressive and anti-inflammatory effects.
International Immunopharmacology published new progress about Allergic contact dermatitis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.
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