Li, Jianhua; Jiang, Chao published the artcile< Palladium-Catalyzed C-H Silylation of Aliphatic Ketones Using an Aminooxyamide Auxiliary>, Application In Synthesis of 112-63-0, the main research area is palladium catalyzed silylation aliphatic ketone aminooxyamide auxiliary; beta silyl ketone preparation.
A Pd-catalyzed β-C(sp3)-H silylation of aliphatic ketones with disilanes to afford β-silyl ketones is reported. The aminooxyamide auxiliary is critical for the C-H activation and silylation. The reaction tolerates a number of functional groups and shows good selectivity in silylating β-C(sp3)-H bonds in the company of C(sp2)-H bonds and acidic α-C(sp3)-H bonds. The reaction is scalable, and the aminooxyamide auxiliary is readily removed to give β-silyl ketones, which could serve as useful building blocks for organic synthesis. Late-stage diversification using this protocol is demonstrated in the silylation of santonin with good yield.
Organic Letters published new progress about Aliphatic ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics