Tomassoli, Isabelle; Gundisch, Daniela published the artcile< The twin drug approach for novel nicotinic acetylcholine receptor ligands>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is nicotinic acetylcholine receptor ligand; 3D QSAR pharmacophore; Nicotinic acetylcholine receptor; Structure–activity relationship; Twin drugs; nAChR.
The association of two pharmacophoric entities generates so-called ‘twin drugs’ or dimer derivatives The authors applied this approach for the design of a small compound library for the interaction with α4β2* nicotinic acetylcholine receptors (nAChRs). In this compound series, the nAChR ligand N,N-dimethyl-2-(pyridin-3-yloxy)ethan-1-amine served as one pharmacol. entity and it was initially kept constant as one part of the ‘twin’ compound ‘Twin’ compounds with identical or nonidentical entities using the ‘no linker mode’ or ‘overlap’ mode were synthesized and evaluated for their nAChR affinities. Compound I showed the highest affinity for the α4β2* nAChR subtype (Ki = 0.188 nM) and its (di)fluoro analogs could retain nanomolar affinities, when replacing pyridine as the hydrogen bond acceptor system by mono- or difluoro-phenyls. The ‘twin drug’ approach proved to provide compounds with high affinity and subtype selectivity for α4β2* nAChRs.
Bioorganic & Medicinal Chemistry published new progress about Homo sapiens. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.
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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics